منابع مشابه
Activation of human platelets by misfolded proteins.
OBJECTIVE Protein misfolding diseases result from the deposition of insoluble protein aggregates that often contain fibrils called amyloid. Amyloids are found in Alzheimer disease, atherosclerosis, diabetes mellitus, and systemic amyloidosis, which are diseases where platelet activation might be implicated. METHODS AND RESULTS We induced amyloid properties in 6 unrelated proteins and found th...
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Intracellular deposition of misfolded protein aggregates into ubiquitin-rich cytoplasmic inclusions is linked to the pathogenesis of many diseases. Why these aggregates form despite the existence of cellular machinery to recognize and degrade misfolded protein and how they are delivered to cytoplasmic inclusions are not known. We have investigated the intracellular fate of cystic fibrosis trans...
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With the assistance of proteins called chaperones, newly translated proteins fold into the three-dimensional shapes that are critical to their function. When proteins fold abnormally or become unstable, the consequences can be dire for cells, particularly neurons, which are exquisitely sensitive to the accumulation of misfolded proteins. Many neurodegenerative diseases, like Parkinson’s and Cre...
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Inam Neuroscience Research Center, Department of Neurology, Sanbon Medical Center, Wonkwang University College of Medicine, Gunpo; Department of Neurology*, Seoul National University College of Medicine & Seoul National University Bundang Hospital, Seoul, Korea During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying patho...
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The accumulation of misfolded proteins in insoluble aggregates within the neuronal cytoplasm is one of the common pathological hallmarks of most adult-onset human neurodegenerative diseases. The clearance of these misfolded proteins may represent a promising therapeutic strategy in these diseases. The two main routes for intracellular protein degradation are the ubiquitin-proteasome and the aut...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2016
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb3381